Cardizem ER - extended release tablets with diltiazem. Antiarrhytmic action is caused by learned suppression of transport of Ca2+ in heart tissues that leads to lengthening of the effective refractory period and delay of carrying out in AV nodosity. Hypotensive action is caused by dilatation of resistive vessels and decrease in TPR. Extent of decrease in arterial blood pressure is correlated with its initial level. It has the minimum influence on smooth muscles of GIT. During long (8 months) therapies tolerance does not develop.
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